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apalutamide will decrease the extent or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with prescription drugs which have been CYP2C19 substrates may result in decreased exposure to those drugs.tazemetostat will reduce the lev